Tag: science

  • Pandemic Considerations

    As an immediate disclaimer, I am a doctor training to be a general practitioner in Ireland and am a member of the Royal College of Physicians of Ireland. I have worked in the local hospital emergency department and Covid assessment hubs as well as a general practice surgery during the pandemic and have seen very unwell patients suffering with Covid-19 and the after-effects of same. I have friends who have lost parents and grandparents and understand the devastating effect that the virus has had on their lives. I absolutely do not underestimate the seriousness of this disease. I am fully vaccinated and recommend that patients are vaccinated should they so wish. I am vehemently against the concept of vaccine mandating and passports. I fully support the right to protest and detest the concept of censorship by large technology companies. I feel that in the current climate of extreme opinions on this topic, I must state all the above. I have no expertise in infectious diseases, public health or epidemiology. Like most doctors, regardless of whether they choose to admit it or not, my understanding of statistics is limited. Hence, I do not offer any opinion in this regard.

    The Doctor in Society

    The Covid-19 pandemic has been an ever-present part of our daily lives for over a year. There is little left to say that has not already been said in relation to the correct management of the virus on a national and international level. It appears – from the approaches of different countries around the globe – that it is impossible to reach anything approaching universal agreement on the best manner of protecting vulnerable people from the disease, while simultaneously protecting vulnerable people who also have suffered terribly because of the restrictive measures that governments have felt it necessary to enact in our societies. Hence, the purpose of this essay is not to provide an opinion as to the approaches adopted, but to discuss and examine some ethical considerations and the implications of our decisions.

    We should first consider the role of a doctor in society. John Berger wrote in A Fortunate Man, a seminal book on the life and work of a dedicated general practitioner in rural England, that ‘like an artist, or like anybody else who believes that his work justifies his life, Sassall – by our society’s miserable standards – is a fortunate man.’[i]

    Certainly, as a vocation, medicine is endlessly interesting and the care of people when they are unwell is incredibly rewarding, despite its demands. There is an intimacy between a doctor and his patient that is intangible and key to a successful therapeutic relationship. We occupy a privileged position in people’s lives as we often meet them when they are at their most vulnerable and most in need of help.

    Note the deliberate use of help as opposed to treatment. I use this word purposely because treatment in the general sense is not always appropriate when trying to improve a patient’s condition. Berger continues that a good doctor can be recognised as someone who ‘meets the deep but unformulated expectation of the sick for a sense of fraternity. He recognises them’. You’ll notice that the recognition does not include intelligence, curiosity or diligence, although these are all welcome attributes.

    Ethical Pillars

    Another important aspect of being a decent doctor in the true sense of the word is to regularly consider the four ethical pillars of medical practice. These are autonomy, justice, beneficence and non-maleficence. Acknowledging and adhering to these principles allows us to help and treat patients in a humane manner and should allow doctors to recognise the limits of our ability to protect people. This is an important point to emphasise. As physicians, we often see ourselves as lifesavers or life-preservers, but this is often not the case and creates unrealistic expectations for both the doctor and patient.

    Our primary function is to prevent unnecessary suffering and death where possible and to try to consider the effects of our treatments not just on the patient, but on the patient’s family and wider community. Beyond the above, we are capable of little else, which is in of itself, no mean feat.

    A significant risk in the practice of medicine is that in the search for ‘progress’, our hubris means that we are trying to cheat death on behalf of the patient with ever-increasing numbers of interventions, with often dubious effects on patients’ quality and quantity of life.

    This is often apparent in the field of oncology. For example, a recent paper published in JAMA in November 2020 examined the clinical trial data available on treatment outcomes of all novel cancer drugs approved for the first time between 2000 and 2016.[ii] 92 novel cancer drugs were approved by the FDA for 100 indications based on data from 127 clinical trials. Despite the enormous cost of both developing and treating patients with these drugs, the median absolute survival benefit was 2.4 months.

    This requires emphasis. 2.4 MONTHS of median survival.

    This is simply staggering and reflects that we may have lost our way in the medical community, approving medications for use without fully appreciating the implications of this decision i.e., if this person receives x drug at x cost, what effect will this have on the healthcare system as a whole? Does treating patients in this manner, with often experimental medications, benefit society as a whole or the pharmaceutical industry? This may require a ‘hard heart’ as described by Jim Stockdale in Thoughts of a Philosophical Fighter Pilot. The correct decision for the many is often the hardest on the few.

    Progress in Medical Science

    It goes without saying that it is essential to strive for progress in science and medicine. This should not require stating as I am in awe of the advances made every day in medical science. It is, however, equally essential to recognise the fundamentals of health and the requirements for same. The UN defines health as not just the absence of disease, it is a state of complete physical, mental and social well-being. Can we say, as doctors, whose role it is to help restore and maintain health, that any of our patients are healthy in the context of the events of past year? Are we striving to help our patients to be healthy or are we only treating their diseases as they develop? There is a subtle but significant difference.

    Ivan Illich, the philosopher, wrote extensively about the effects, both good and bad of doctors and medicine on not just the individual but on society in general.[iii]3 He recognised the amazing large-scale innovations in public health that have given us access to good food, safe water, sewage disposal etc, but he also recognised the potential for medicine and the medical profession to cause significant harm. The focus of his arguments relate to the adverse impact of medicine on society. His principal argument being that the medical profession was eroding the individual’s capacity to accept suffering and more importantly, the capacity to die one’s own death.

    As previously mentioned, our duty is to ameliorate suffering where possible and allow patients to suffer and die with dignity when this is appropriate. Our attempts to do more has the potential to lead to catastrophe, both physically and psychologically, because it can permanently remove a patient’s perception of control over their own being. Prominent examples include the current opioid epidemic in the US and benzodiazepine addiction issues here in Ireland. All developed under the guise of attempting to alleviate suffering, but instead mutating to continue to cause devastation to this day.

    Overdose deaths involving opioids, including prescription opioids, heroin, and synthetic opioids (like fentanyl), have increased over six times since 1999.[iv] Most of these deaths are attributable, unintentionally or not, to the medical profession. This is a sad reality. Simply because a treatment decision is well-intentioned does not protect the doctor or the patient from unintended circumstances.

    Hence, I would advocate where at all possible, conservative or ‘light touch’ medicine, promoting patient empowerment and autonomy. Where possible, I suggest promoting the ideal of health provided by William Landen: ‘To ensure good health; eat lightly, breathe deeply, live moderately, cultivate cheerfulness and maintain an interest in life’.

    Latter-day Clergy

    Physicians should be an occasional addendum to life; instead, we have increasingly assumed the role previously held by the clergy. This is not a positive development. Although the medical profession has not asked for this endowment, it has accepted it without significant resistance or understanding of the spiritual nature of the role. Many physicians are not consciously aware of the transference, creating further patient dependence and maladaptive behaviour patterns, creating the class of people known to doctors as ‘heart-sink’ patients. Medicalisation of existential angst manifesting as vague abdominal pain serves neither the doctor, the patient, nor society in general.

    Public health is an extension of medicine that is remarkably important but often ignored at a societal level. It has been defined simply as the science and art of preventing disease and is tasked with the promotion and protection of the health of entire populations. This is a gargantuan task and is arguably much more important than the other, more visible fields of medicine. While the aims of public health medicine are admirable, it would be easy to deduce that multiple aspects of modern public health, beyond the basics mentioned previously, had been failing miserably up to the onset of the pandemic.

    Levels of both child and adult obesity as well as type 2 diabetes are increasing year on year, chronic disease continues to over-burden every western healthcare system and smoking rates remain stubbornly high globally. All these issues, created by the cultures of excess and consumption that we inhabit, are likely to worsen in the years ahead, with multiplicative effects on successive generations in Ireland to the point where it is expected that our life expectancy and more importantly, healthspan, will decrease in the years ahead.[v]

    I mention this to illustrate the point that people rarely behave in a rational manner. This is especially evident at a population level. Therefore, one could logically decide in a public health capacity, to intervene in increasingly intrusive ways to ultimately improve the health of the population, through restriction of access to unhealthy pastimes and products. This would presumably entail banning cigarettes, alcohol, highly processed junk food and all other manners of potentially unhealthy choices. This would reduce the burden on our hospitals in both the short and long-term and allow improved access to care for a happier, healthier population.

    For example, the government of Bhutan has banned all sales of cigarettes in their country, with excellent health effects to date. The Prime Minister of Bhutan took the decision because he stated that it was the right thing to do for the health of the country’s citizens.[vi]

    However, it would be argued vociferously that any such decrees would impinge on an individual’s rights to individual choice, not to mention the enormous loss in tax revenue to the State from the sale of such items. The Irish government is estimated to generate two billion euro a year in tax revenue from the sale of cigarettes alone. Interestingly, it is estimated that we spend the same amount on the management of smoking-related diseases in our healthcare system, thus negating this as an argument against banning cigarettes.

    If this were indeed implemented in Ireland, and more particularly in the case of alcohol, there would be immediate cries of excessive intervention in the private lives of the citizens of the State. This would be a perfectly reasonable argument in the absence of a state of emergency, such as we find ourselves in over the course of the past fifteen months.

    It must be stated that the effects of cigarettes and alcohol are not limited to the individual. Anyone who argues this has not had to wait for an outpatient appointment in an overcrowded cardiology or respiratory clinic for three years. One should remember though, that there has been a healthcare and trolley ‘emergency’ in Ireland since Mary Harney announced one twenty years ago and there has been no improvement whatsoever in the annual crisis figures, with increasing amounts of the State budget allocated to the attempted provision of healthcare. In 2018, the Irish state spent €22.5 billion on the healthcare system, which equates to 11.4% of Gross National Income (GNI).[vii] People blame the healthcare system but the system, while dysfunctional, may not truly be to blame. Perhaps, as a society, should we shoulder some of the responsibility?

    State Interventions in Pandemics

    Thus, after thinking about some of the arguments that could be made for state intervention in the lives of its citizens, I think it is important to consider the various ethical approaches that could underpin our ongoing approach to the pandemic.

    A utilitarian approach was initially adopted by the UK government, aiming for the concept of achieving herd immunity to maximise the collective interest. As is commonly known, this was quickly abandoned as the healthcare system came under increasing strain. This approach is not without precedent, and I do not refer to the management plan decided upon by the Swedish government.

    In 1968, the world was struck by an influenza pandemic known as the ‘Hong Kong flu’, killing approximately 4 million people globally, according to the Encyclopaedia Britannica. A paper published in The Lancet examined the response to the 1968 pandemic and noted that the British government was extremely passive in its approach.[viii]

    Fearing that the press would have a field day if it issued a prominent warning about the pandemic, it left it to local medical officers of health to decide on the most appropriate course of action. Interestingly, publishers were also reluctant to risk stoking public fears, ‘a reflection perhaps of heightened anxieties due to the Cold War and the launch of Sputnik, as well as greater respect for medical experts and deference to authority’. This approach undoubtedly led to many deaths and interestingly, affected people under the age of 65 more than the elderly.

    It can certainly be argued that the fabric of British society was maintained at the time, possibly for the greater good in terms of long-term ramifications. Contrast this with the media response to the pandemic today. The Guardian newspaper is one of many which has a live ‘coronavirus update’ section on its website for the past year. Does the information provided serve the individual or the advertisers paying for space?

    Ireland’s Kantian Approach

    By way of comparison, Ireland seems to have adopted a Kantian approach to the management of the pandemic. It is unclear whether this is by accident or by design. In an interesting paper by Gerard Delanty, he quotes the philosopher Jurgen Habernass, the world’s leading political philosopher.[ix]11 He stated that ‘the efforts of the State to save every single human life must have absolute priority over a utilitarian offsetting of the undesirable economic costs’. This equates to, in layman’s terms, ‘lockdown first, ask human rights questions later.’

    While Kantian ideals are superficially attractive, I worry that the implications of following such an approach will have long-term repercussions. One can argue that that the degree of government overreach into the lives of its citizens is deontologically unacceptable and that multiple human rights violations have occurred in this country and may occur again in the near future.

    A report commissioned by the Irish Human Rights and Equality Commission in 2020 stated that ‘not only is Covid-19 more than a public health crisis, but it is also arguably the most significant set of human rights and equality challenges that Ireland has ever faced’[x]12 The report highlights multiple areas of concern regarding the State’s and NPHET’s issuing and maintenance of emergency powers. Principally, these included the blurring of the boundaries between legal requirements and public health guidance, the potential for emergency measures and their enforcement to disproportionately affect certain disadvantaged and more vulnerable groups and the lack of human rights and equality expertise in the decision-making structure put in place to tackle the pandemic, or in the systems that implement and scrutinise these decisions.

    These are significant issues that have not been acknowledged or addressed by the Government or NPHET. This should be of significant concern as it belies the seriousness of the situation. I must stress that I do not suggest that NPHET or the government are made up of morally ambiguous people. They are not the real issue. I honestly believe that they are decent people working hard in the most extraordinary circumstances that we have witnessed in most of our lifetimes. It is in this ‘state of exception’ however, that we must be at our most fierce in the assiduous monitoring and protection of our civil liberties.

    Overreach?

    Giorgio Agamben, the Italian philosopher, has warned repeatedly against the implementation and continuation of emergency powers as a normal paradigm of government.[xi] He questions the imposed limitation of freedom in a desire for perceived safety and security and has previously discussed this issue in his examination of the surveillance powers afforded to the US government after the events of 9/11. He warns against fear and stresses the importance of society guarding itself against any form of extreme government, regardless of perceived benevolence.

    Matthew Crawford, the philosopher cum motorcycle mechanic, also warns against the culture of ‘safetyism’, describing a cycle whereby ‘the safer we become, the more intolerable any further risk becomes’ and that ‘once emergency powers are passed, they are seldom relinquished.[xii]

    Do we genuinely believe in Ireland that we are immune to benevolent autocracy? Has the question even been asked in the public domain here? Does the absence of questioning and discussion not demonstrate the lack of any public intellectual discourse that might be useful to allow individuals to consider their own ethical responsibilities in a pandemic?

    By corralling people in their homes, the State has acted as a helicopter parent, pacifying us with off-licences and pandemic unemployment payments. The decision was made that people were not trustworthy enough to consider their fellow man and behave accordingly.

    Anti-lockdown campaigners have repeatedly pointed to the relative ‘success story’ of Sweden in its approach to the pandemic. Perhaps, it has nothing to do with the manner of the imposition of the restrictions but to do with how seriously the population took the virus and were satisfied to adhere to advice from the public health authorities. There was reciprocal trust between the State and its’ people. Because essentially, that is the difference between the population groups.

    I would ask people to ignore the behaviour of the virus and instead to consider how people in different countries behave on an individual basis. In Japan, lockdowns have not occurred as they are deemed illegal. However, anecdotally, they take virus very seriously and take what could be regarded as excessive personal risk avoidance i.e., wearing hazmat suits in airports when travelling (this was witnessed recently in Charles de Gaulle Airport in Paris).

    Again, I must re-state that I do not believe that lockdown decisions in Ireland were made with ill-intention. They were made to ostensibly protect the vulnerable in society i.e., the elderly. By and large, despite some nursing home and hospital scandals, this has been effective and a healthcare system, bloated and over-burdened for decades, has avoided a presumed disaster. These are the benefits of the most prolonged and nominally if not practically, the most stringent lockdown measures in Europe.

    The Law of Unintended Consequences

    However, one should also consider and cite the law of unintended consequences i.e., that the actions of governments always have effects that are not anticipated. Hence, it would be unrealistic to assume that our seventeen months of restrictions will have no harmful side-effects. Unfortunately, the vulnerable in society are still those who have and will suffer the most.

    Elderly patients, the focus of our concern, have deconditioned before my eyes over the course of the three lockdowns enacted here and many of my colleagues are reporting similar experiences. Loss of muscle and bone strength has a direct impact on the morbidity and mortality of an elderly population.[xiii]

    Physically active older adults (≥60 years) are at a reduced risk of all-cause and cardiovascular mortality, breast and prostate cancer, fractures, recurrent falls, ADL disability and functional limitation and cognitive decline, dementia, Alzheimer’s disease, and depression. They also experience healthier ageing trajectories, better quality of life and improved cognitive functioning. Inactivity over the past seventeen months will have dreadful ramifications for a significant proportion of the people that we have sought to protect.

    They spend their time with their families in a state of anxiety, fearful of becoming unwell but also guilty at the burden placed on their families. Loneliness and social isolation have increased dramatically. This will have multiplicative effects in the years to come as there is a strong body of evidence to demonstrate that cognitive decline and mortality rates are doubled among people who suffer because of isolation and loneliness.[xiv]

    The ESRI now predicts that tens of thousands of people will permanently lose their jobs, and that up to 250,000 will remain unemployed at the end of 2021[xv]17. Perhaps many of these jobs would have been lost because of the pandemic and not the restrictions, but the negative societal impact of such job losses on people in lower socioeconomic groups cannot be overstated, further worsening inequality and poverty.

    In Ireland, the lockdown has been an inconvenience for the middle class, but I state without hesitation, that the longer this persists, the more devastating the blow will be to the vulnerable in society and the more difficult it will be to recover.

    Socioeconomic Status

    Socioeconomic status has a much more significant impact on health status than medicine and medical care. To provide a stark example, In England, the gap in life expectancy (LE) at birth between the least and most deprived areas was 9.4 years for males and 7.4 years for females in 2015 to 2017; for healthy life expectancy (HLE) it was 19.1 years and 18.8 years respectively.[xvi] This is in one of the richest countries in the world, with a socialised healthcare system lauded and envied globally. It is essential that we remember this fact if we wish to strive for a decent society. I stress again that lockdowns and continued restrictions will affect the most deprived in our own society and further widen the gap of income inequality.

    Finally, the effect of state intervention must be considered on the most vulnerable cohort in society, our children. Lockdowns have been demonstrated to have increased the number of adverse childhood experiences suffered by vulnerable children.[xvii]

    The common argument in favour of lockdowns is that their adverse effects are not multiplicative. I would argue the opposite. The longer these measures remain in place, the larger the long-term effects on children. A study in Oxford demonstrated that children had essentially learned nothing over the course of the pandemic year through Zoom.[xviii]. It is estimated that 100,000 children did not return to school in the UK after the most recent lockdown or were defined as ‘severely absent.’[xix] When will disadvantaged children regain the educational ground that they have lost and what will be the effect of this life on their adult lives?

    The government tells us to stay safe and hold firm, slogans that signify nothing except a lack of imagination. They asked that the citizens of the State protect the health service by adhering to stay at home guidelines, which were enforceable by law. The question must be asked why the State has not applied the same urgency to the trolley and hospital bed crisis, which has been present annually for at least twenty years?

    How many poor people have died unnecessarily because of over-crowding or inequitable access to healthcare services? Why was the Cervical check scandal allowed to unfold? Why the Mother and Baby Home scandal? Why are we building a behemoth Children’s Hospital that is arguably not suitable for purpose and will be by its’ finish, the most expensive hospital in the world? Why does this occur while there are 193,600 children living in poverty in Ireland,[xx] considering the wealth that this country currently generates. One should ask is the state truly worried about its citizens or its systems of ‘care’? There is a significant difference.

    Viktor Frankl

    Finally, we should consider the role of the individual in this pandemic. Victor Frankl, the famous neurologist and founder of logotherapy, wrote about the nature of life and its meaning in the context of his experiences as a prisoner in Auschwitz and his subsequent return to society.

    In Man’s Search for Meaning and Yes to Life, he explores the themes of meaning and his own treatment of patients with severe mental illness. In summary, his own severe despair, which often afflicted him, only served to convince him further of its meaning and the importance of finding meaning in life.

    This does not necessarily mean happiness as this is a more modern obsession. We have no right to happiness in the modern sense. Life does not expect you to be happy or sad or any other emotional state. Life simply is. Within these confines, which are as limited or limitless as you choose, what you emotionally feel during this period is your interpretation of the experience, nothing more or less.

    Tragedy constantly stalks us and will visit at various points during our lives, regardless of external environmental factors. As a result, negative visualisation is a concept that the Stoics advocate. Marcus Aurelius wrote of putting his children to bed at night and imagining them dying. This was not done in a sociopathic sense, but to remind him of the precious time that he had with his children, to value this time and to appreciate that they may be taken from him at any point.

    Perhaps, societally, we could improve our lot by engaging in this thought process more often, not to upset us but to improve our appreciation of what we have now and to steel ourselves against the difficulties that we may face in the future. It encourages difficult thinking and bravery. It may often be easier to retreat to the arms of someone/something else to make decisions for you but is this the correct decision? This pandemic is an external, unfair devastation but I believe that our society, as imperfect and flawed as it is, can adjust and limp forward. I trust in people to make the correct decisions for themselves at this point in the pandemic.

    In Summary

    I repeat my claim to no expertise on the management of a pandemic. As a doctor, I am asked to assess people’s problems, both medical and otherwise on multiple occasions throughout my daily work. While I am required to make my decision with relative confidence where possible, key to being a decent physician is to constantly consider that I may be wrong in my treatment decision and that my differential diagnosis remains broad.

    I believe that at this point, ongoing and future mandated restrictions are likely to be more harmful than beneficial to society and that we should carefully consider the course that we plot and what we value in life. Safety should not be valued above all else and iatrogenesis has terrible implications for health. I write this on a day when NPHET has recommended to government that indoor dining should be restricted to people who are fully vaccinated only. Is this what we have become?

    All images © Daniele Idini

    [i] Berger J. A Fortunate Man: the story of a country doctor. London: RCGP; 2005

    [ii] Ladanie A, Schmitt AM, Speich B, et al. Clinical Trial Evidence Supporting US Food and Drug Administration Approval of Novel Cancer Therapies Between 2000 and 2016. JAMA Netw Open. 2020;3(11):e2024406. doi:10.1001/jamanetworkopen.2020.24406

    [iii] Illich, I. (1975). Medical nemesis: The expropriation of health. London: Calder & Boyars.

    [iv] Wide-ranging online data for epidemiologic research (WONDER). Atlanta, GA: CDC, National Center for Health Statistics; 2020.

    [v] Woolf SH, Schoomaker H. Life Expectancy and Mortality Rates in the United States, 1959-2017. JAMA. 2019;322(20):1996–2016. doi:10.1001/jama.2019.16932

    [vi] Ugen S Bhutan: the world’s most advanced tobacco control nation? Tobacco Control 2003;12:431-433.

    [vii] CSO https://www.cso.ie/en/releasesandpublications/ep/p-syi/statisticalyearbookofireland2020/soc/health/

    [viii] Honigsbaum M: Revisiting the 1957 and 1968 influenza pandemics The Lancet 13–19 June 2020 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247790/

    [ix] Delanty, Gerard (2020) Six political philosophies in search of a virus: critical perspectives on the coronavirus pandemic. Discussion Paper. London School of Economics, London https://www.lse.ac.uk/european-institute/Assets/Documents/LEQS-Discussion-Papers/LEQSPaper156.pdf

    [x] Irish Humans Rights and Equality Commission, https://www.ihrec.ie/documents/irelands-emergency-powers-during-the-covid-19-pandemic/

    [xi] Stephen Humphreys, Legalizing Lawlessness: On Giorgio Agamben’s State of ExceptionEuropean Journal of International Law, Volume 17, Issue 3, 1 June 2006, Pages 677–687, https://academic.oup.com/ejil/article/17/3/677/2756274

    [xii] Matthew Crawford, ‘The Hypocrisy of Safetyism’, Unherd, May 15th, 2020, https://unherd.com/2020/05/the-hypocrisy-of-safetyism/

    [xiii] Hwang, T., Rabheru, K., Peisah, C., Reichman, W., & Ikeda, M. (2020). Loneliness and social isolation during the COVID-19 pandemic. International Psychogeriatrics, 32(10), 1217-1220. doi:10.1017/S1041610220000988 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306546/

    [xiv] Hwang, T., Rabheru, K., Peisah, C., Reichman, W., & Ikeda, M. (2020). Loneliness and social isolation during the COVID-19 pandemic. International Psychogeriatrics, 32(10), 1217-1220. doi:10.1017/S1041610220000988

    [xv] Quarterly Economic Commentary, Spring, 2021, ESRI, https://www.esri.ie/system/files/publications/QEC2021SPR_0.pdf

    [xvi] Office of National Statistics, https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/healthinequalities/bulletins/healthstatelifeexpectanciesbyindexofmultipledeprivationimd/2015to2017/

    [xvii] Per Engzell, Arun Frey, Mark D. Verhagen  Learning loss due to school closures during the COVID-19 pandemic Proceedings of the National Academy of Sciences Apr 2021, 118 (17) e2022376118; DOI: 10.1073/pnas.2022376118 https://www.pnas.org/content/118/17/e2022376118

    [xviii] ‘Kids can’t catch up if they don’t show up’ The Centre for Social Justice,  https://www.centreforsocialjustice.org.uk/library/kids-cant-catch-up-if-they-dont-show-up?utm_medium=email&utm_source=CampaignMonitor_Editorial&utm_campaign=LNCH%20%2020210628%20%20House%20ads%20%20JO+CID_c144dc407b002e4fa6548baa2389bf59

    [xix] Ibid https://www.centreforsocialjustice.org.uk/library/kids-cant-catch-up-if-they-dont-show-up?utm_medium=email&utm_source=CampaignMonitor_Editorial&utm_campaign=LNCH%20%2020210628%20%20House%20ads%20%20JO+CID_c144dc407b002e4fa6548baa2389bf59

    [xx] Social Justice Ireland, https://www.socialjustice.ie/content/policy-issues/more-637000-people-are-still-living-poverty-ireland-despite-modest

     

  • Could Ivermectin End the Pandemic?

    The bacterium streptomyces avermitilis was discovered by Satoshi Omura at the Kitasato Institute in Japan in conjunction with William C. Campbell at MSD (Merck, Sharpe and Dome) in the early 1970s. From this compound the medicine Ivermectin was developed. Ever since, it has proved a wonder drug for the treatment of parasites in humans and animals.

    Most of these infections occur in Africa and Latin America, but it was nevertheless a lucrative drug for MSD. Nonetheless, in 1987 they provided the drug to the world free of charge as the Kitasato Institute gave up rights to any further royalties from its sale. This was an exceptionally generous gesture as it was a $1 billion per year product, and had been for several years. Its extensive and widespread use in humans has been described by Chris Whitty, Chief Scientific Advisor to the British government throughout the COVID-19 pandemic as ‘a drug with a good safety profile’, with a serious adverse drug reaction rate of 1/800,000

    Another paper says ‘Ivermectin was generally well tolerated with no indication of associated CNS (central nervous system) toxicity for doses up to 10 times the highest FDA approved dose of 200mcg/Kg’. In a nutshell, it is a safe drug, in use for a long time, and the nuances of clinical usage are therefore known to many physicians.

    A recent paper from India using ivermectin as a preventative used 15mg on average, twice per month at a cost of $1.20 per month in healthcare workers resulted in a 72% reduction in infections. In a recent online enquiry to a wholesaler in India I was offered 100 x 3mg tablets for $12. Yet remarkably this same dose in Ireland would cost €100 per month.

    As is well known by now, in early 2020 the WHO alerted the world to a pandemic virus that apparently emerged out of China, a virus for which there was no known treatment available and which was most dangerous in elderly patients with underlying conditions.

    The illness presented with cold-like symptoms that after a period of between five and eight days could develop into severe respiratory symptoms, requiring hospitalisation and sadly in some cases leading to death.

    Guidelines for General Practitioners

    The Irish College of General Practitioners stated in their guidelines to general practitioners in April 2020: ‘Clinicians should be aware of the potential for some patients to rapidly deteriorate one week after illness onset’ (members access only: https://www.icgp.ie/speck/properties/asset-Interim Guidance for General Practitioners).

    The same document lists those conditions and age groups in which this is a possibility. It goes on to state that ‘no medications have shown any therapeutic benefit on the progress of Covid-19 pneumonia.’

    This advice has not been updated since April 2020. So ‘do nothing until the patient turns blue’ appears to be the invaluable advice from a national body sixteen months into this crisis. However, in the spring of 2020 if you were unfortunate enough to find yourself in a nursing home your blue pallor would not summon the arrival of a flashing blue light, but instead you would receive midazolam and morphine, both respiratory depressants, whilst you awaited the Grim Reaper.

    GPs were discouraged from examining their patients. Even the use of the stethoscope was deemed unnecessary. Shades of blue were everything. The ‘do nothing’ approach is still supported in the guidelines issued by HIQA in February 2021, despite over forty studies demonstrating the efficacy of ivermectin in the intervening period.

    HIQA Advice

    HIQA currently advise that ‘individuals do not prescribe or use interventions for the treatment of COVID-19 that do not meet the necessary minimum criteria’, but don’t outline what these criteria are.

    They go on to ensure that ‘practitioners are not criticised for not prescribing these interventions.’ This latter is a somewhat curious statement if a body is so confident that their evaluation of the evidence is above reproach.

    Yet William C. Campbell co-discoverer of Ivermectin with Satoshi Omura – with whom he shared the Nobel prize – in a speech to the Royal Irish Academy in April 2020 stated: ‘there is the possibility that a safe dosage of Ivermectin might reduce the rate of viral replication in the mammalian body, or affect the virus in other ways that might be revealed by further research.’

    Ivermectin (IVM) bound to a C. elegans GluClR.

    Fortunately for some Irish patients, a few brave GPs looked beyond this island for guidance. Asking doctors to do nothing, and specifically indicating certain actions that they should not take, is a restriction that disconcerts many experienced doctors, if not being a downright interference in the doctor-patient relationship.

    As GPs in the community we deal with people who are part of a family within a social setting. We are therefore cognisant of many features of health – which outsiders might consider superfluous to the ‘science of medicine’.

    Now I laugh each time someone juxtaposes those words, especially when I consider the absolute chaos that is general practice’s interaction with people. At the end of some consultations, I’m lucky to be able to spell my own name correctly, let alone apply the cold, steely, rational logic of science to solving any problems.

    But no matter how chaotic or complex, or even futile, medical interventions may be, one must never vanquish a patient’s hope. Even when close to death, hope – if not for further life at least for a peaceful death – is something the GP can bring to the situation.

    So who are these people in the ICGP or HIQA to say to GPs that there are no treatments available for their vulnerable patient who develops a SARS-CoV2 infection; to say ‘well let’s wait and see, and sure if you turn blue we’ll get an ambulance’?

    We won’t visit or examine you, and you won’t be coming to our surgeries, but we’ll look after you by proxy. So why were we as doctors advised to do nothing? Not even to try a cheap, effective and safe drug, if only to elicit the placebo effect?

    Criminal Charges

    In India WHO’s chief scientist Dr Soumya Swaminathan is facing criminal proceedings brought by the Indian Bar Association for disseminating disinformation about ivermectin and its effectiveness as a preventative and early treatment for SARS-CoV2 infection.

    Should those in HIQA who made recommendations to Irish doctors not face similar charges? Is this not a case of wilful blindness?

    In the USA two distinct groups of doctors-intensive care physicians lead by Drs Pierre Kory and Paul E. Marik set up the FLCCCA (Front Line Covid Critical Care Alliance), and community-based physicians led by Professor Peter McCullough of Texas A+M University, in conjunction with AAPS (American Association of Physicians and Surgeons), devised protocols in their respective fields using Ivermectin and other medications, deemed ineffective by the WHO.

    https://www.youtube.com/watch?v=dEmOCWOZPk8

    Their rationale was based on medical ethics and a professional desire to give their patients a fighting chance against this condition. They have faced vilification and attempted sanctions, as have doctors in Ireland who were simply trying to help their patients. And some patients even had the temerity to get better.

    I’m not sure what irked the Medical Council of Ireland more, the survival of the patients despite being given a HIQA/WHO proscribed substance, or some previous impotence at not being able to impose their second hand thoughts on all members of the medical profession.

    There is no money in helping patients as the current system is set up. One makes more money merely by ascertaining how ill someone is by using the phone. Even if these medications do nothing beyond the placebo effect why has there been a concerted effort to block the use of what has already been shown to be a relatively low risk intervention?

    Meta-Analysis

    The most recent Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines by Laurie, Bryant et al in the American Journal of Therapeutics found a 62% reduction in death in a meta-analysis of fifteen RCTs. It concludes:

    Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.

    The WHO’s own assessment of seven trials showing an 81% risk reduction was diminished in significance because of ‘imprecisions’ resulting in the WHO falling short of recommending the use of ivermectin. Fudge, fudge and more fudge.

    Let’s cut to the chase here with this and perhaps many other substances. There are powerful vested interests steering advisory bodies away from the evidence, buying up integrity and burying it in a deep dark place.

    The current vaccines are deemed to be the only safe and reliable treatments. This is ironic given that these products are all still in phase 3 trials, and safety data will not be fully available until late 2022 at the earliest.

    The fact is that emergency use authorisations (EUAs) issued by the FDA in America and the EMA in Europe are contingent on there being no other treatments available in a public health emergency deemed to be effective. This is about money, vast sums of money. It is about wilful blindness at the highest echelons of the WHO, national governments and so called scientific advisory bodies.

    It is about conflicts of interest, and the damaging and intellectually limiting dependency that science has placed on large corporations, and it would seem that now governments are in the same stranglehold.

    As it is often said, the first casualty of war is truth. Clearly this also applies to pandemics, where body counts mean money, power and influence. And as in war inflation of body counts has always been good for business. Death may evoke much front of camera hand wringing but behind the scenes there is even more palm rubbing and back slapping.

  • Covid-19: Unanswered Questions

    Confusion and fear are to be expected in novel situations where experience is limited; this should fade as understanding grows. Such is the natural cycle. When governments employ behavioural psychologists to induce fears in order to control and coerce the population, however, we have to question their motives and methods.

    Initially we were advised that a zoonotic virus crossed species: horseshoe bat to pangolin and then to humans, via the food chain. Ghastly images were shown nightly of a range of exotic creatures that Chinese people – portrayed in somewhat xenophobic terms because of their, to us, foreign tastes – supposedly enjoy consuming. This outbreak witnessed sagacious, and wealthy, heads knowingly saying ‘I told you so.’

    And apparently we can expect much more, and worse, in the future because of the ways in which we live and eat. Last year any question of whether it could have come from any other source was shot down as absurd by dubious fact checkers, and freighted with conspiracy theory fairy dust.

    This despite Wuhan containing a level 4 BSL laboratory, and three members of its staff being hospitalised in November 2019 with coronavirus-like respiratory symptoms. Furthermore, this same laboratory was conducting gain of function research into coronaviruses, through a grant form EcoHealth Alliance, an organisation funded by U.S. National Institutes for Health. This type of research using viruses was banned by the Obama administration as being too risky.

    Weaponising

    This same research is not far removed from the process of weaponising a pathogenic organism. So why did NIH fund this laboratory to carry out this type of research, and who else knew of the potential risks, and incentives, for finding a novel infective agent and researching possible treatments and vaccines?

    The first we in the West learnt about any of this came from the videos on TV and social media of people dropping dead in the street – in hindsight clearly not coronavirus cases – and the Chinese locking down it citizens. Next there was Italy, with coffins being carted away by military trucks.

    These were all carefully orchestrated publicity stunts, but who was responsible? Who decided to broadcast uncritically these sensational images? The world took note, a pandemic was declared and governments around the world, almost uniformly, imposed harsh and unprecedented restrictive measures on their citizens.

    In Britain the initial plan was to protect the vulnerable, through cocooning, whilst awaiting herd immunity in the young. But there followed a swift turnaround in the face of public outcry. In Europe only Sweden resisted the clamour to lockdown and was pilloried in the international media. ‘Sweden has become the World’s Cautionary Tale’ declared The New York Times in July, 2020.

    The British government’s approach was strongly influenced by the epidemiological modelling of Imperial College’s Professor Neil Ferguson, of previous forecasting fiascos. For example, he predicted three to four million deaths from Swine Flu in 2009, which ultimately resulted in less than 300,000 global fatalities.

    Ferguson’s Imperial paper predicted 500,000 deaths in the U.K. in an unmitigated scenario, and on March 20th, told the New York Times that the ‘best case outcome’ for the U.S. was a death toll of 1.1 million, rising to 2.2 million in a worst case scenario. As of June, the U.S. has seen just over 600,000 deaths, and the U.K. 127,945, in circumstances where the attribution of death to Covid-19 is often deceptive.

    Further doom and gloom laden scenarios was provided by Professor Christian Drosten, head of the institute of virology, Charite university hospital, Berlin, while alternate modelling provided by Professor Michael Levitt, Stanford University and Nobel laureate was ignored.

    PCR Testing

    Dorsten’s main contribution to this story is his paper ‘Detection of 2019 novel corona virus by real time RT-PCR’ outlining the basis for the widely used Drosten-PCR test that has been criticised for multiple errors, and the haste with which it was published. This test is now the most widely used diagnostic test for Sars-CoV2.

    This is despite its invenor Kary Mullis’s – Nobel laureate for chemistry for his work with PCR – stating unequivocally ‘it doesn’t tell you if you are sick’.

    https://twitter.com/zaidzamanhamid/status/1384873889591873536

    There are a number of criticisms of the Drosten method in that he reportedly developed it using partial genetic sequences provided by the Chinese, in conjunction with sequences from other corona viruses. Furthermore, the test which according to Kary Mullis is a quantitative test, is not reported to clinicians this way.

    Instead a qualitative result ‘detected’ or ’not detected’ is reported without giving the cycle threshold, even after the WHO suggested physicians should be given this figure. The significance of the cycle threshold harks back to Kary Mullis’s ‘it doesn’t tell you if you are sick.’ Even Dr Anthony Fauci of the NIAID (National Institute of Allergy and Infectious Diseases) has stated that at ct values of greater than 35 it is unlikely that any live virus is present in the patient.

    https://twitter.com/jimgris/status/1326518250386063361?lang=en

    Why then did Irish laboratories use ct values as high as 45? And why did we go from testing inpatients with PCR, knowing the false positive rate, to the community setting and especially the asymptomatic, given asymptomatics are often ‘false positives’, leading to an inflated ‘case’ count.

    One has to wonder if the state’s spending of an estimated €400 million on PCR testing has been a case of noses in the trough not wanting to avoid the public smelling the coffee. Who were the people with vested or conflicted interests in this issue?

    Churchillian Speeches

    Most Western governments, including Australia and New Zealand, paraded their respective Prime Ministers before the cameras to make speeches of Churchillian gravity, implicitly likening the threat of Sars-CoV2 to World War II. Leo Varadkar even paraphrased Churchill in his first speech to the nation -’never will so many ask so much of so few,’ before imposing unprecedented draconian lockdown measures, based on fear.

    Along the way we have heard words of caution from notable academics including Stanford Professors John Ioannidis and Jay Bhattacharya, as well as Professor Sunetra Gupta of Oxford University. But these voices were hardly ever heard on Irish mainstream media.

    These authorities cautioned that measures would disproportionately hurt the poor and vulnerable; that severe illness was mainly confined to a recognisable cohort, and that there was no evidence for the efficacy of lockdown measures.

    Nobody listened. Instead the government closed schools, prevented people from earning a living, stopped all cultural and sporting activity, prohibited religious worship and confined travel to within five kilometres of home.

    For months elderly people languished alone in nursing homes and hospitals, some dying alone; women gave birth without their partners; funeral rites were severely curtailed, as basic civil rights were completely ignored in response to an illness with an estimated infection fatality rate of 0.05% for anyone under the age of seventy years.

    Every night the state broadcaster became the government’s harbinger of doom with the recitation of nightly death tolls. What purpose other than ratcheting up of fear did this serve?

    Through the diligent questioning of Michael McNamara TD, however, we know that the reported mortality figures included anyone testing positive in the previous twenty-eight days with a PCR test, no matter what their underlying condition. Deaths unassociated with Sars-CoV2 were obviously irrelevant.

    They turned out to be very relevant as the CSO annual death figures of 6.4 per 1000, which were little different to previous years, and even less than 2013. Why then, when death figures dropped, did reporting switch to the spurious concept of ‘cases’, defined by a positive PCR test? Why did the Irish government shamefully enlist the services of RTE in terrifying the nation, and why did the state broadcaster acquiesce? Answers on the back of a postcard…

    Disproportionately Affected

    The message ‘we are all in this together’ was a big lie. The disease disproportionately killed people over the age of eighty, especially those in nursing homes, many of whom were needlessly infected after being transferred to hospitals with testing withdrawn at the height of the pandemic in spring 2020. The obese, those with diabetes, chronic heart and lung diseases are also disproportionately affected.

    These pre-existing morbidities are more prevalent among lower socioeconomic groups in society. So we were clearly never all in this together.

    Civil servants, including politicians and the medical profession, those working in IT and for media corporations, could easily work from home, but nearly half a million people had to stop work for the duration, especially those in the tourism and hospitality sectors. These are mainly young people, and like children, most would only have been mildly effected by the virus. So why were they forced to suffer unnecessarily?

    Moreover, why did small retail outlets have to close for months on end, while off licenses and fast food chains were deemed essential services?!

    States of Fear

    The kind of Propaganda devised by Sigmund Freud’s grandson Edward Bernays who infamously made it fashionable for women to smoke, was evident in the government’s manipulation of the figures, and the media’s delivery. Bernays wrote in Propaganda (1928) ‘The conscious and intelligent manipulation of the organised habits and opinions of the masses is an important element in democratic society.’

    A host of celebrity scientists appeared, many with Conor McGregor levels of empathy, only better elocution, a gentler demeanour and less tattoos. Trite experiments were undertaken on popular TV shows, where we found dour funereal forecasts from infectious disease experts, who were invariably wrong in their predictions, and inane squeaking from a misplaced neuroscience.

    All of these ‘experts’ sang in unison. Dissenting voices were heard briefly and infrequently. Some lost their jobs merely for disagreeing with the bull-in-a-china shop approach taken by the HSE/NPHET/government.

    In her new book States of Fear Laura Dodsworth outlines how the UK government used behavioural psychologists, probably via their Nudge unit, to control the population through the deployment of carefully selected ‘experts’ and repetitive messaging on news broadcasting.

    This was substantiated in the recent testimonies by Dominic Cummings, the former chief adviser to Boris Johnson. ISAG were also familiar with scaremongering techniques, as intercepted emails highlight their tactic of targeting and discrediting individuals, and keeping fear ramped up as a tool in their ZeroCovid campaign.

    To quote Bernays again ‘there are invisible rulers who control the destinies of millions. It is not generally realised to what extent the words and actions of our most influential public men are dictated by shrewd persons operating behind the scene.’

    Using this sinister playbook, between them NPHET, ISAG and the government managed to sow a level of fear, suspicion and division in society that may take years to unravel.

    Flatten the Curve?

    Despite all the hype around flattening the curve to save the health service at the beginning of the pandemic, and the use of draconian measures to do so, alas nothing was done to treat patients at home.

    Several readily available, cheap and relatively safe products, were hypothesised to have positive benefits in the early stages of a Sars-CoV2 infection, but there were systematic efforts to steer physicians away from these.

    The ICGP guidelines for GPs on the treatment of early Sars-CoV2 amounts to do nothing, and wait for patients to get better, or if they fall really ill send them into hospital. Some doctors in the USA lost their licenses for prescribing these medications, and others in Ireland faced censure by the Medical Council.

    According to physicians like Peter McCullough, Professor of Medicine at Baylor University, Texas in conjunction with AAPS (The association of American Physicians and Surgeons), and separately Dr Pierre Kory of FLCCCA (Front Line Covid Critical Care Alliance) Sars-CoV2 was empirically treatable, especially in that first week before the patient became very unwell.

    https://vimeo.com/560523610

    So, despite a concerted effort to vilify them, they treated their patients. Why did Irish GPs, save for a few, fail to do so?

    In doing nothing did many patients needlessly died? With our widespread application of lockdowns and our disregard for focused protection measures, as advocated by the Great Barrington Declaration (which has garnered 850,000 signatures, including 43,000 from medical practitioners) coupled with our refusal to at least try and treat patients, have we done a great disservice to our patients?

    Silencing of Dissent

    Sweden did not adopt anything like the same draconian measures, and their economy and society has not been disrupted to anything like the same extent as Ireland’s. Yet their mortality figures compare favourably, especially when adjusted for the relative age of each population.

    Perhaps one of the main reasons for the concerted campaign to ensure that no other treatments were deemed suitable for the early treatment or prevention of the disease was the FDA criterion for an EUA (emergency use exemption).  No such exemption would have been granted to a product in such an early stage of development, without animal or human study data, except in what are deemed to be extraordinary circumstances.

    €26 billion – the amount Pfizer expects to earn this year after producing the first Covid-19 vaccine – might buy a lot of scientific validation, and political influence.

    The undue haste with which these vaccines have been rolled out demands sceptical enquiry, especially in relation to two particular cohorts: pregnant women and children. As clinicians we generally exercise extreme caution in these groups.

    So why is it that for a condition with an overall IFR of 0.15% have we discarded this caution? Linking vaccination status to the right to work, travel, attend cultural and sporting events is divisive, coercing those who wish to exercise a degree of caution and/or exercise autonomy over their health.

    Without the questionable concept that is asymptomatic spread, there is no justification for vaccinating anyone in low risk groups, and certainly no justification for using bully tactics.

    Despite all these glaring questions, there has been a deafening silence from the medical profession in Ireland, and those that have spoken out have been quickly silenced. Is this how we are going to deal with complex issues in future? Adopting binary, categorical approaches without nuance leaves no room for debate.

    RTE have paid lip service to the notion of an informed debate, hosting Martin Feeley and then later pitching Professors John Lee and Sunetra Gupta into debate with hand-picked stalwarts.

    Moneybags

    In Ireland today scepticism is viewed as a contagion to be eradicated, with compliance seen as the perfect state of health. As a nation we must ask: why have so many been so quiet; why has fear replaced reason, and groupthink taken over once again?

    One must question the role of doctors ‘stuffing their mouths with gold’ as Aneurin Bevan put it in relation to British doctors at the inception of the NHS. A quick look at the 2019 PCRS payments to GPs shows a healthy €85 million in government expenditure. This, however, mushroomed to over €200 million for the same period in 2020.

    Some were clearly making a killing during the pandemic. And whose idea was it to advise doctors not to see patients face-to-face during the pandemic? If a doctor won’t see you who will?

    Further to this windfall will be vaccination payments at a cool €60 per patient. Is it any wonder GPs want everyone vaccinated?

    There may even be boosters for variants required for everyone on the planet! The media should be asking the question: who is benefitting from this Monty-Pythonesque situation?

    Certainly any government with the slightest authoritarian bent, which it transpires appears to be most Western ‘democracies’. It really is worrying how little opposition there has been to Chinese-inspired lockdowns, with opponents dismissed as a far right fringe – even by the apparently left-wing opposition – despite the obvious damage these policies have done to the poorest, who were also least protected by the measures.

    Why did so many European governments fall into line so quickly, when even a passing familiarity with EU politics would indicate that it can take years for Member States to agree on the number of legs that the average cow possesses?

    If you intuit that something is just not right, and baulk at jingoistic phrases like ‘the new normal’ and ‘build back better’ ask yourself cui bono or ‘who benefits’, and don’t let the fear of being labelled a ‘conspiracy theorist’ dissuade you from asking reasonable questions.

    Feature Image: Daniele Idini

  • Covid-19: A Deadly Deception

    4,915. And rising. This number can only increase or, at best, stay the same. It can never go down. Of all the innovations that governments and media around the world have come up with, seemingly independently of each other, during the ongoing Covid period perhaps the most insidious is the daily running total of deaths.

    I have often wondered what purpose this number serves. At a time when we are frequently told by the media and government to ‘follow the science’, what could be more unscientific than a figure which, even when nobody is dying, looms above us as a warning that danger is ever present and nothing has improved.

    But take the number of people who are unemployed, a figure that has reached terrifying proportions without any sophistry or assistance from behavioural scientists. In fact, a lot of effort is expended on massaging this number downwards from the actual amount to levels more palatable for public consumption.

    But imagine that we calculated the number of unemployed by concocting a total of all those who have been laid off – jobs that have died – at any time and for any duration, during the past thirteen months? Or since unemployment began, a running total of all the people who have been unemployed ever?

    What function would that number serve? Might it help prevent future unemployment? Might it better inform us of the skills and training required for our workforce? Might it be useful for analysis and reporting? As Frankie Howerd used to say, “Nay, nay, and thrice nay.” I wager any civil servant who proposed such an idea would soon be on their way to early retirement, and be about as popular with politicians as a Garda on breathalyzer duty outside Leinster House.

    Yet that’s exactly what we do with the running death total (and its near twin the running case total) for Covid. If the purpose of this number is to show where we currently stand amidst the ebbs and flows of the pandemic, then surely a monthly or a weekly total would do the job better. We could then, as we do with the unemployment figure, compare this month to last (or this week to last) and judge which way we’re going. Are we moving steadily forwards? Are we tumbling hopelessly backwards? You get the idea.

    Why haven’t we ever had a running total of deaths from cancer, heart attacks or diabetes? If we’d started even a year ago, these numbers would be at impressive levels now. Cancer and diseases of the circulatory and respiratory systems certainly dwarf the Covid tally.

    Surprisingly, Worldometer hasn’t tried to do something like this. To many of us, Worldometer is the central hub of running Covid death totals. Currently, it trumpets a formidable 593,148 deaths for the United States, a daunting 127,570 for the United Kingdom and, as mentioned at the start, a not inconsiderable 4,915 for Ireland.

    But what do these frightening numbers refer to? Well, they refer to the number of Covid-19 deaths. So what’s all the fuss about? The fuss is over what constitutes a Covid-19 death. So what is meant, exactly, by a Covid-19 death? Here is where it starts to get a bit complicated.

    WHO Guidance

    On April 16th 2020, the World Health Organisation (WHO) issued a document entitled “International Guidelines for Certification and Classification (Coding) of Covid-19 as Cause of Death. This provided strict rules for registration of Covid-19 deaths, rules which were fundamentally different to those which were in place for the registration of deaths from other causes.

    Some doctors expressed concern about what they felt would give a misleading picture of causes of mortality. These rules, they said, were unprecedented and would lead to the over-reporting of deaths from Covid-19 and the under-reporting of deaths from other causes. Their warnings went unheeded and, for the most part, unreported. There was no place for prudence and common sense amid the frenzy and hysteria of the early days of the pandemic.

    Even CMO Tony Holohan acknowledged in April last year: ‘Clinically, the “index of suspicion” for the disease would be “a good deal higher” than would normally be the case for flu.’

    Since then numerous medical professionals have added their voices to this dissenting chorus. The latest Patrick O’ Connor is coroner for Mayo and public information officer of the Coroners Society of Ireland. O’Connor has expressed his discomfort at official reporting of Covid-19 deaths in this country: “I think numbers that are recorded as Covid deaths may be inaccurate and do not have a scientific basis”, he said earlier this month.

    Let’s take a look at the International Medical Certificate of Cause of Death (MCCD). For this section I am indebted to Dr. No, the author of the ‘Bad Medicine’ blog, for his succinct explanation of how the MCCD works and how, in practice, the WHO guidelines affect this process. I recommend his article about this if you want a more detailed understanding of the topic.

    The MCCD was introduced by the WHO in 1948. Its purpose was to create an international standard for the recording of deaths and to describe the sequence of events which led to a death, rather than just the immediate cause (as was common in many countries at that time).

    Frame A (above) is the most important part of the MCCD. It is here that all significant information about a death is recorded. As you can see, Frame A has 2 boxes. Box 1 is for recording the cause of death, Box 2 is for recording contributing conditions. Box 1, the cause of death box, has four lines: the first line records the immediate cause of death, the remaining lines record any conditions which led to the immediate cause of death, with the last line containing the underlying cause of death. The idea is to record the sequence of events which led to the death.

    To give an example. A person with diabetes dies from a heart attack, which was caused by heart disease.

    So the first line in Box 1 contains ‘Myocardial Infarction’ (the clinical name for a heart attack) because a heart attack was the immediate cause of death. The second line contains ‘Ischaemic Heart Disease’ (the clinical name for heart disease) because this is the underlying cause of death. This is the condition which initiated the sequence of events which culminated in the person’s death: the heart disease led to a heart attack. The remaining lines in Box 1 are left blank because this person had no other conditions which contributed to the sequence of events leading to their death. Diabetes is recorded in Box 2 because this is a contributing condition, rather than being a part of the sequence of events which led to death. This death will be registered as ischaemic heart disease (or simply heart disease) because this is the underlying cause of death.

    Another example. A person dies from internal bleeding due to a ruptured artery as the result of a road traffic accident.

    The first line in Box 1 contains ‘Internal Bleeding’ because this is the immediate cause of death.

    The second line contains ‘Ruptured Artery’ because this is what led to the internal bleeding.

    The third line contains ‘Road Traffic Accident’, as this was the underlying cause of death: it was a road traffic accident which initiated the sequence of events that led to the death. In this instance, Box 2 is left blank as there were no contributing conditions. So, the road traffic accident led to the ruptured artery which led to the internal bleeding. This death will be registered as a road traffic accident.

    “clinically compatible illness”

    The WHO’s guidelines define a Covid-19 death as “a death resulting from a clinically compatible illness, in a probable or confirmed COVID-19 case, unless there is a clear alternative cause of death that cannot be related to COVID disease (e.g. trauma).” This is an extremely vague definition and one which allows for a rather broad interpretation of what can be considered a Covid-19 death.

    As can be seen from the HSE’s website or that of the UK’s NHS, there is a large overlap between the symptoms of Covid-19 and those of any number of other respiratory conditions or Influenza Like Illnesses (ILIs). Any of these other conditions can be considered a “clinically compatible illness”. You will note that Covid does not have to be confirmed: a “probable” case is sufficient for inclusion as a death. As Dr. No puts it, “If it looks like Covid-19, it is Covid-19.”

    The guidance goes on: “A death due to COVID-19 may not be attributed to another disease (e.g. cancer) and should be counted independently of preexisting conditions that are suspected of triggering a severe course of COVID-19.” This is very important. What physicians are being told here is that, when they have identified a Covid-19 death (using the loose “if it looks like Covid” definition), then regardless of any pre-existing conditions which may have triggered severe Covid-19, the death must be registered and counted as a Covid-19 death. This goes against all conventions for identifying the cause of death.

    So how does this relate to our MCCD form? Well, in our earlier examples of somebody dying from a heart attack and somebody dying in a road traffic accident, there should be no difference in the way the deaths are recorded. In fairness to the WHO, they are quite clear in their guidance that these two types of death should not be recorded as Covid-19. (Unfortunately, this has not stopped overzealous authorities around the world from registering heart failure, motor accidents, suicides and murders as Covid deaths).

    However, when it comes to most other types of death, we start getting into murky waters. Take the example of a person who dies from pneumonia, caused by immobilisation, which itself was caused by multiple sclerosis.

    In this case, the underlying cause of death is multiple sclerosis. Why? Because multiple sclerosis led to immobilisation which led to pneumonia. So this death will be registered as multiple sclerosis.

    Now, let’s imagine this person had tested positive for Covid-19.

    Notice anything strange? Because of the WHO guidelines, the underlying cause of death is no longer multiple sclerosis, but is instead Covid-19. Multiple sclerosis (and immobilisation) gets moved to Box 2, it’s now been relegated to a contributing condition. This death will be registered as Covid-19. Remember the WHO said in their guidelines “A death due to Covid-19 may not be attributed to another disease and should be counted independently of pre-existing conditions.”

    Testing Flaws

    A further issue with the above example is that the presence of Covid-19 is determined solely on the basis of a positive PCR test result. According to the WHO’s clinical coding instructions, a death must be registered as Covid-19 if the patient received a positive test result, even if they never displayed any symptoms. But PCR tests are notoriously unreliable, with even the WHO themselves warning of their tendency to produce false positive results.

    So here we have the case of an unfortunate individual whose multiple sclerosis, over many years, caused them to become immobile. Immobility, sadly, can lead to pneumonia which, especially for the aged and/or immunocompromised, often results in death. However, because of the WHO guidance, the presence of a positive PCR result alone means that all of their medical history, the entire chain of events which led up to the person’s death, is cast aside and replaced by the misleading explanation of Covid-19.

    But the issue goes even deeper. You’ll recall that the WHO’s definition of a Covid-19 death includes “probable” cases as well as “confirmed” ones. Our final example describes an individual who dies from acute respiratory distress syndrome (ARDS), caused by pneumonia, which itself was caused by chronic obstructive pulmonary disorder (COPD).

    As you can see, the underlying cause of death is COPD, which led to pneumonia, which led to ARDS. This death will, of course, be registered as COPD.

    But what if this person had had contact with someone known to have Covid-19 or even with a person suspected of having it? Here’s what would happen to the MCCD:

    The underlying cause of death is now ‘suspected Covid-19’, which, in the figures we see on the nightly news and in the vast majority of statistics made available by governments, is treated in exactly the same way as a confirmed Covid-19 death. The WHO’s clinical coding instructions insist that it is, so long as the deceased had “contact with (a) confirmed or probable case.” The COPD which caused this person’s pneumonia is cast aside, no longer considered to have played a part in the sequence of events that led to their death.

    This is absurd. Yet this is how deaths around the world are now being recorded and registered. If somebody is dying of heart disease, liver disease, respiratory disease, cancer, dementia or any other terminal illness, and they have a positive PCR test or have simply been in contact with somebody suspected of having Covid, their death is now registered and counted as a Covid-19 death. Any pre-existing condition, no matter how serious and no matter what part it played in their ultimate demise, is moved to Box 2 of the MCCD and not recorded as the underlying cause of death. The WHO guidelines state, in the section entitled “Comorbidities”, that “if the decedent had existing chronic conditions…they should be reported in Part 2 of the medical certificate of cause of death.” Conditions which for more than seventy years, since the introduction of the MCCD form, have been understood as underlying causes of death, are now rebranded as contributing factors. All to make way for the mighty Covid.

    Massive Inflation

    The result is a massive inflation of the numbers of Covid-19 deaths. As Patrick O’Connor, the Mayo coroner, says, when speaking about terminally ill patients, “If they prove to be Covid positive in a test, it is that (Covid) which is recorded as the principal cause of death — even though that person may have been terminally ill with a short life-expectancy prior to such testing.” And, as we have seen, a test is not even necessary, as the WHO’s guidelines instruct physicians to include “probable” with “clinically compatible” illnesses in the tallies.

    Even before the WHO issued their guidelines on 16th April last year, Italian authorities had been using a similar method to register Covid deaths, with 88% of patients there (up to March 20th, 2020) having at least one comorbidity and many having two or three. In addition to hugely inflating the number of deaths from Covid-19, this bizarre way of counting also distorts the mortality rate of the disease, making it seem far more deadly than it actually is.

    In 2020, a total of 73,444 people died in England and Wales with Covid-19 recorded as their underlying cause of death. In response to a freedom of information request, on 29th March 2021, the UK’s Office for National Statistics revealed that only 9,400 (12.8%) of that number were recorded without pre-existing conditions.

    On July 3rd last, Ireland’s then acting Taoiseach, Leo Varadkar, tweeted, “In Ireland we counted all deaths in all settings, suspected cases even when no lab test was done, and included people with underlying terminal illnesses who died with Covid but not of it”, revealing that the numbers of Covid-19 deaths in Ireland were vastly exaggerated and in no way reflected the lethality of the disease in this country.

    Although the complete death statistics for 2020 have not yet been made available for Ireland, in April, 2021 Kildare coroner Professor Denis Cusack published a report analysing deaths in that county during the pandemic. Of 230 deaths recorded with Covid-19 as the underlying cause, 228 (99.13%) had pre-existing conditions.

    Fewer than 1% Died Without a Comorbidity

    I would have thought that this was a significant finding, that fewer than 1% of the people who died from Covid-19 in County Kildare did not have comorbidities. But, like anything else that doesn’t fit in with their campaign of terror against the Irish people, the Irish media was having none of it. While both RTE and The Irish Times gave coverage to Professor Cusack’s report, neither had anything to say about the 99.13% of Kildare’s Covid dead who had pre-existing medical conditions. Nor was there a mention of the average age of death in this cohort being 82.2 years of age. Both news services instead chose to focus on selected aspects of the report which they used to support the ‘lethal virus’ narrative they have long pushed. Is this censorship? Maybe it’s just extremely poor journalism.

    The running total of deaths is one of the pillars that supports this whole charade. The narrative of a deadly pandemic would never have worked without the impression of huge numbers of fatalities, countless lives ‘lost to Covid’. The unprecedented changes in the way deaths are counted allowed this to happen. You would imagine such a fundamental change, one which has had such a colossal impact on every man, woman and child on the planet, would be widely reported and discussed. Yet it is almost impossible to find a mention of it anywhere in the mainstream media.

    Although most of us have suffered under the heel of draconian Covid regulations, and will continue to suffer, some have profited greatly from this fiasco. We have seen how health scares have been manipulated for gain in the past, none more so than the Swine Flu pandemic that never was, in 2009, when governments, the WHO and pharmaceutical corporations colluded to profit at our expense.

    There needs to be an urgent investigation, on a global scale, to find out how the Covid pantomime was allowed to happen. And we need one in Ireland, to determine who knew what and when, and exactly who has benefitted.

    Walk-in Testing Centres

    The current narrative being spun in Ireland is that we are close to ‘finding a way out’ of lockdown and that, if we behave ourselves, we might be permitted some limited freedoms during the summer. This is hardly surprising. We’re coming to the end of coronavirus season, which means it’s so much harder to inflate ‘cases’. And because mortality rates in the Northern Hemisphere are typically at their lowest during the summer months, it’s not as easy to attribute huge numbers of deaths to Covid-19. It was the same last summer.

    But the government has been preparing for this. Already, there are 5 walk-in testing centres in operation in Ireland, with many more planned – a perfect way to boost the numbers and keep us on our toes for the summer months. And, of course, the government reserves the right, at any moment, to slap us all back into lockdown.

    At the same time, it has been made abundantly clear that whatever limited freedoms we might be permitted will be contingent on mass vaccination and, before long, vaccine passports and digital identity. And don’t forget, coronavirus season comes around again in September. But, as we have seen, the lethality of this disease, for which we’ve radically changed the way we live and have forsworn so much of our freedom, has been blown out of all proportion by the fraudulent way in which deaths are registered.

    We suffered under austerity for a decade. It’s hard to believe that the same politicians who decimated our health service, causing untold hardship and death, now want to protect us. Do we trust they are spending our money honestly and wisely? How much is being spent on mass vaccination, testing, tracing, the vaccine passport infrastructure? And what is the cost of the Covid period to our economy? The whole circus makes a mockery of the years of austerity and of every person who suffered because of them.

    Cost to our Health

    Then there is the cost to our health. Many have lost their lives because of this deception, but you don’t see a running total of their deaths on the news every night. How many have died due to a lack of primary health care, which has been sidelined and neglected, sacrificed at the altar of Covid? How many cancelled surgeries and missed screenings? What about those in urgent need of treatment who were too frightened to attend a hospital? And those who were turned away before they even reached a hospital, because Gardai at a checkpoint deemed their need not sufficiently urgent?

    The mental health of our nation has taken a nosedive, not due to Covid but because of lockdowns and other unwarranted sanctions against our people. Loneliness, depression and despair have all taken their toll. The US Centres for Disease Control and Prevention (CDC), hardly a radical anti-lockdown stronghold, has estimated that one third of all excess mortality in the United States during 2020 was due to reasons other than Covid-19.

    We’ve been deceived. When important facts are left out of a narrative in order to foster a misconception, we call it lying by omission. We have been lied to by politicians, public health officials, wealthy media barons and the stooges who write for them. And we have paid a terrible price. In the twilight of our freedom, it’s time for us to stand up for the truth.

  • ‘Healthy People Do Not Require Genetic Vaccination’

    Editor’s Note: Having previously published Vaccination: A Matter of Trust with Caveats, we now anticipate objections from some readers to an article that may provoke vaccine hesitancy, at a point when rapid rollout to the entire adult population is widely touted as the only path out of interminable lockdowns. The author of this article, Dr. Marcus de Brun, however, is a medical doctor, and prior to his resignation last year– in protest against the government’s handling of the pandemic – a member of the Irish Medical Council. He also holds a first class degree in microbiology from TCD. Thus, we believe it is incumbent on Cassandra Voices as ‘a home for independent voices to inspire new thinking’ to provide this platform for him to articulate fully a public stance that he would not vaccinate a healthy person with any of the four vaccines currently on offer in Ireland. All the more so in a period of crisis, we maintain it is vital to give space to informed arguments that go against the grain. We invite comment and/or rebuttal, and ask if you appreciate this article that you offer a contribution to this publication, either through signing up with us on Patreon or through a single donation Buy Me A Coffee.

     

    Having recently stated publicly that I would ‘not administer a genetic-vaccine to a healthy animal, never mind a ‘healthy human being,’ I have been asked by friends (and foes) to clarify this statement, and will attempt to do so here.

    At present, vaccines produced by four companies (Pfizer, Moderna, Astra Zeneca and Johnson & Johnson) are available on the European market. All four are ‘genetic vaccines’ in that they are composed of synthetic DNA or RNA that is contained within a membrane or shell. In construction and appearance the vaccine is very similar to the SARS-CoV-2 virus responsible for the coronavirus disease known as Covid-19. The vaccine gains entry to human cells by a process that is almost identical to the manner by which a virus generally gains access to host cells. This process is called ‘transfection’.

    Each of these vaccines work by introducing either DNA or RNA into host cells. The genetic material then instructs host cells to make a piece of the coronavirus (the spike protein) that is then released into the blood stream or tissues. There, the spike protein will trigger an immune response. Following this immune response, the vaccinated individual will retain some immunity; they will have antibodies and white cells that can now recognise Covid-19 and attack it before it has a chance to cause a serious infection.

    The AstraZeneca and Johnson & Johnson vaccines are DNA vaccines,[i] which transfect DNA into the Nucleus of host cells. The Pfizer and Moderna Vaccines are RNA vaccines, these transfect their RNA into the cytoplasm of host cells. The difference will be explained later; however, the initial process is the same: human cells take up synthetic viral genes, those genes then direct those cells to begin manufacturing the spike-protein of Covid-19. The cells will then release the nascent spike-protein into the bloodstream or tissues, where it will then function as a ‘traditional vaccine.’

    In essence, the distinction between genetic-vaccines and ‘traditional vaccines’ is that the latter would involve a person being injected with killed or inactive virus or spike-protein, which would then cause our immune systems to mount a response. Each of these novel genetic-vaccines however, insert genetic material into human cells. These synthetic genes then ‘hijack’ those cells or ‘convert’ them to manufacture and release the spike-protein. With a genetic vaccine, pharma does not make the vaccine, our own cells are programmed to do the work instead, a process entirely different from that of a ‘traditional vaccine’.

    Out with the Old…

    For the first time in my medical career of some twenty years, I am presented with the apparent necessity of vaccinating young healthy people with experimental vaccines, against a disease for which they have little or no risk of suffering life-threatening,[ii] or even serious long-term[iii] illness. The vast majority of  ‘vulnerable’ people to whom they might pass Covid-19 have already been either vaccinated or been exposed to the virus.[iv]

    In Ireland according to our Central Statistics Office, during the past 12 months up to the end of January 2021; amongst the entire population of 1-24yr olds, there have been 55,565 PCR confirmed cases of Covid-19. Out of those cases, there has not been a single death recorded; from, by, or associated with Covid-19.[v] It has been reported that a single Covid-related death in this cohort (1-24yrs) did occur in February of this year. However, this has yet to appear in the figures published by the CSO.

    Young nurses, medical staff, care workers, are being pressured into taking a vaccine they probably don’t need themselves, despite residents under their care having been almost all vaccinated already. Now Covid-19 genetic-vaccines are being tested upon children as young as six months old.[vi]

    A Scarcity of Serious Questions? Or a Scarcity of Serious Media?

    The justification for many, if not most, policies during this crisis has largely been based on ‘mortality data’. In contrast, Swedish authorities have enforced relatively few restrictions, nor made masks mandatory. In Ireland, the CSO indicate that 92% of all Covid-related deaths have occurred in those over 65 years of age.[vii]

    In Sweden that cohort of their population is 3.17 times greater Ireland’s. Thus, if we roughly compare the Swedish mortality total (at the time of writing) of 13,262,  to the Irish total of 4588, and if we then multiply the Irish mortality total by 3.17, we arrive at a figure of 14,544, which is significantly higher than the comparable Swedish total.

    We are crudely, but reasonably, comparing ‘like with like’ to reveal glaring potential problems with our own relatively draconian Covid policies. When compared with Sweden, our own version of lockdown seems to have had no benefit in terms of preventing mortality. It might not be unreasonable to assert that our stricter policies may have contributed to a relatively higher mortality. Yet, perhaps the biggest question here is: why are there so few questions being posed in the media in respect of the efficacy of masks, lockdowns or vaccination policies?

    On the rare occasion questions are raised in our national media, it as if an ‘anti-vaxxer’, ‘right-wing loon’, or political extremist is trying to gate crash what might otherwise be a rather sedate and respectable party.

    Pro-Vaxxer

    In the good old days before Covid, in Ireland, and around the world, we only vaccinated those who were vulnerable to, or at risk from a specific disease. We still vaccinate children against an array of illnesses that adults have not been, and are not routinely vaccinated against; Rotavirus and Meningitis B are but two obvious examples. Adults are equally susceptible to infection by either, but they are not as vulnerable to serious illness, and so are not vaccinated. Previously, we only ever vaccinated the vulnerable and those at risk; recently, however, that good science and common sense has been turned on its head.

    It is suggested that we should vaccinate young healthy people who have little if anything to fear from Covid-19. A paediatric genetic-vaccine is expected to be available later this year. It is argued that even though children are generally not susceptible to serious disease, they should be vaccinated in order to protect the vulnerable and achieve ‘herd-immunity.’ In the meantime, the vulnerable have in large part already been either been vaccinated already, exposed or sadly passed away.

    In a recent post on Twitter Michael Levitt, Nobel Laureate and Professor of Biophysics at Stanford University said:

    If getting the disease does not give immunity, how do you think that a vaccine that makes the same spike protein as the virus makes will give immunity?

    It beggars belief that with over a quarter of a million cases of Covid-19 already confirmed in Ireland, [viii] those who have already contracted the virus, are not at least being offered antibody testing prior to being offered (or pressured into taking) a new type of vaccine; novel vaccine that have recognised associated risks, and have not completed all safety trials.

    Between March and June, 2020, 96% of additional deaths related to COVID-19 in Europe occurred in patients aged older than 70 years [ix] We have clearly lost sight of whom we are trying to protect, and what we are trying to protect them from. Presently we have a national obsession with conformity, and an ostensible adherence to guidelines. Despite empirical truths, and substantial contrary evidence, we are being corralled into what increasingly appears to be a specific belief-system surrounding Covid-19, and its threat to the entire population.

    Those who have read George Orwell’s Animal Farm (1945) will be familiar with the threats issued to the hapless animals: ‘Jones the farmer will return, and destroy all of your good work!’ In contemporary parlance, he will return with ‘Long Covid,’[x] and frightening ‘New Variants’ with him.

    https://twitter.com/bergerbell/status/1379143927542947841

    Politicians have applied policies that are in keeping with this notion of ‘universal severity’ in response to a virus where 86% of those infected did not have virus symptoms, such as cough, fever, and loss of taste or smell., according to a UK study from October.[xi] Many of our Covid policies arrive with the benefit of preserving established governments from demonstrations and assemblies calling for policy revisions and or enquiries.

    My own calls for a public enquiry into nursing home deaths, or my pleas on behalf of common sense and natural science, are at best ignored by media. As are those of colleagues who feel and believe as I do, including Limerick GP Dr. Pat Morrissey, and Wexford GP Dr Gerry Waters, who was recently suspended by the Medical Council for refusing to adhere to and promote current public health guidance. Others who have openly spoken out against current policies have been subjected to investigation by the Medical Council, and ongoing vilification by many of our peers. Speaking out returns precious few short term dividends.

    Throughout much of Europe since the outset of the crisis, governments, like our own, are presently controlled by proxy scientific-panels or unelected expert committees. Governments claim to be simply ‘following their scientists advice,’ whilst the scientists insist that they are merely informing the government and not directing government policy. In this apparently blameless political ‘no man’s land’, the stage is perfectly set for blameless political atrocities.

    War of the Words: ‘Genetic vs ‘Traditional’

    Many scientists and physicians prefer to describe most Covid-19 vaccines as ‘gene therapy’. It is a phrase that no doubt serves as much to antagonise proponents, as it does to inform them. However, it is as good a place as anywhere to start.

    Genetic vaccines are certainly not ‘traditional’ vaccines. The licence for their use against Covid-19 throughout Europe was granted under emergency legislation that permits manufacturers to skip phase 4 safety trials that would have otherwise delayed their distribution. Advocates insist that skipping this final phase was absolutely necessary to resolve the current crisis.

    There is much to this argument, and we will not dive into it here. However, one point should be made. There are at least two off-patent (cheap and safe) drugs, Hydroxychloroquine and Ivermectin, that may be effective in treating Covid-19. These drugs are not, however, licensed for use in treating Covid in many Western countries, (particularly the wealthier ones who can afford the novel vaccines).

    https://twitter.com/EvidenceLimited/status/1379400534000594945

    If either, or both, drugs had been licensed, this might have proved an obstacle to the granting of emergency use licences for Covid-19 vaccines. The reason for this is that grounds for emergency licensing of genetic-vaccines are substantially reinforced, as long as there are no other pharmacological treatments available at the time.

    Edward Jenner (1749-1823)

    A Traditional ‘Vaccine’

    In China the practice of inoculation against diseases such as smallpox was established as far back as 200 BC.[xii] It is likely that traditional medicine, tribesmen and ancient civilisations used, or at least inadvertently ‘knew’ something of the benefits of limited exposure to a disease, in order to establish some degree of immunity.

    Our own modern era of the ‘traditional’ vaccine begins when Edward Jenner (1749-1823) noticed that milkmaids appeared to be relatively immune to smallpox, a viral illness that was, in Jenner’s day, responsible for widespread suffering and death.

    Jenner observed that something was being transmitted from the cows to the milkmaids, effectively protecting them against smallpox. Cows contract cowpox. It’s not the same disease as smallpox, but as the respective viruses are so similar, whenever the hands of a milkmaid came into contact with a blister or pox on the udder of a cow infected with cow-pox; the milkmaid would be exposed to this very similar virus.

    In these instances the cowpox virus or ‘pieces’ of it, would enter the milkmaid’s blood stream through a cut or minor abrasion on her hands. The virus would be identified by her immune system as a ‘pathogen’ or disease-causing agent. White cells would attack the cowpox virus, causing it to break apart. Those same white cells would manufacture antibodies; little Y-shaped proteins that will stick to surface-proteins on the virus, and cause it to be directly destroyed, or recognised by other white cells that will mobilise to destroy it.

    All of this complex immunology would of course be occurring within the milkmaid’s blood, whilst she happily milked her cows. She might notice a slight blister, a little pus, or minor swelling around one of the abrasions on her overworked hands. The slight redness might be ignored, and would inevitably fade away. However this localised reaction would have heralded exposure to cowpox. The cowpox antibodies would then persist in her blood, remaining attached to the surface of many of her circulating white blood cells; protecting her or “vaccinating” her against small-pox.

    If the milkmaid should later come into contact with smallpox, those newly formed cowpox antibodies would be ready to mount an early and more efficient immune response. Her antibodies to the cowpox virus could attach to the smallpox virus, recruit other white cells – killer t-cells etc – onto the scene, and mount a pre-emptive response. This would be fast enough to eradicate the smallpox infection before it had an opportunity to spread and cause severe illness or death. It was Jenner’s genius that ultimately brought this reality to light.

    Jenner collected some of the pus that oozed from the udders of cows infected with cowpox. He swirled it about in a drop of water, placed it in a glass vial and then offered it to the world as the prevention for small-pox. Half a century later Louis Pasteur coined the phrase ‘vaccination’ after vacca, the Latin for cow. The paradigm in respect of human medicine and public health had shifted forever.

    Louis Pasteur.

    Perhaps the real hero of the vaccination story was an eight-year-old boy by the name of James Phipps, the son of Jenner’s gardener. On May 14th 1796, Jenner made a small incision into James’s arm, and rubbed in a drop of his magical ‘pus-paste’, making little James the first to be given a vaccine in the modern sense.

    Thankfully, little James proved immune to the various small-pox ‘exposures’ and challenges that Jenner then came up with. At the time small-pox was responsible for almost 10% of annual deaths in England. Jenner sent his results in a paper to the Royal Society for publication, but his paper was ignored.

    Having had the audacity to suggest pus from an infected cow’s udder, as a cure for smallpox, Jenner was at first dismissed as an eccentric by his peers. Yet, rather than disappearing into obscurity, he persisted. He vaccinated a further twenty-three people, and having seen little James survive, he even included his own eleven-month old son Robert, in this first ever vaccine trial.

    At that stage the medical establishment found it impossible to ignore his findings, which soon attracted widespread interest amongst the medical fraternity. However, it was not until 1840, some forty-four-years after his first attempt to publish his results, that the British Government began offering Jenner’s vaccination, free of charge, to the general public.

    The same but different

    Since Jenner’s day, ‘traditional vaccines’ have functioned in precisely the same way. Pharmaceutical companies take a virus or bacterium, they break it up, kill it, or leave it intact but render it weaker or ineffective ‘the same but different.’ They then take the bug (or pieces of the bug), swish them around in a little drop of water, add in a few elements that act as preservatives and immune-stimulants; then we doctors inject those pieces into people, thereby preventing many from succumbing to various infective diseases. The vaccination exposes us to a bug or pieces of a bug causing our immune system to generate antibodies and white blood cells that will persist in our circulation and be ready to launch a pre-emptive strike against the bug or a similar bug if it is encountered again: we have, in essence, become immune.

    So what is different about genetic-vaccines? Well here’s where the story becomes a little nuanced. Let’s try to put it in terms we might relate to.

    To begin with we must remind ourselves that: all living things are composed of cells, which is perhaps the most basic tenet of biology.

    Image of a recreated 1918 influenza virus.

    Viruses are not considered ‘living things’, because they are not ‘cells’ and neither are they made up of cells. They are formally referred to as ‘obligate intracellular parasites.’ They only become ‘alive;’ and can only replicate, after entering host cells, at which point they replicate or multiply within host cells. Once inside a cell the virus hijacks the cell’s own processes for making things that the cell needs for itself. The infected cell then becomes a virus factory, it swells with new virus particles, until it bursts, dies, and releases its payload of new virions into the bloodstream, or fluid outside of the cell membrane.

    It is only when a virus is outside the cell, within the blood stream or tissues, that it might be recognised by white cells or antibodies, and become the subject of an immune response. When a virus is inside one of our cells, there are some discrete ways this cell can let other cells know that it has become infected; there are means by which the immune system detects that one of our own cells has a virus inside it. However, these are comparatively slow, indefinite and uncertain processes and will not be discussed here. The major and most important way the immune system clears viruses is by getting at them before they get inside our cells.

    Once a virus is inside a cell, for the most part, it is hidden from the immune system. This point will be crucial to understanding the distinction between a genetic vaccine, and a traditional vaccine.

    All Cells Look a Little, or a Lot, Like a Fried Egg:

    Under a microscope, all cells appear a little like fried eggs. Almost all of them have the same basic plan, the yellow yolk being the nucleus; the white of the egg, the ‘cytoplasm;’ and the outer margin of the fried egg (the crispy brown edge) being the ‘cell membrane’ or wall surrounding the cell. To learn the basics of how genetic vaccines work, we need only refer to this analogy, but we must understand our ‘egg’ a little better before we put the toast on.

    The yellow yolk, or nucleus, contains all of our DNA. To understand what DNA looks like, imagine your fly, not the one buzzing at the window, but the zip on your trousers. It is composed of two sides or strands that are linked together when your zipper is up, and separated when your zipper is down.

    DNA is like an extremely long length of closed zip. Imagine this super long ‘zip’ coiled into individual space-saving packages, like neat balls of wool. Each of these little packages is called a chromosome and (with the exception of sperm cells and egg cells) the nucleus of each of our cells contains forty-six of these little balls of wool; twenty-three from mum, and twenty-three from dad.

    All forty-six are packed into the nucleus, the yellow yolk of our analogous egg. When we, or one of our cells, needs something; a protein, a hormone, a replacement part etc., the information to make what the cell needs (the recipe for all of life’s necessities) is coded for in that length of closed zip, our DNA.

    Each of the ‘teeth’ along the length of the zip strands, represent a single letter of the genetic code. An entire message may contain many letters, or teeth, along a specific length or piece of the zip. The lengths of zip that contain messages (or recipes) are called our ‘genes.’

    The ‘message’ within a gene is like a recipe in a cookbook. It contains a coded instruction for how to make the protein, enzyme etc., or whatever it is that the cell wants or needs. The DNA code is in the nucleus, and the basic ingredients are located in the cytoplasm, and it is in the cytoplasm (the egg-white) where the item required is assembled and manufactured. The raw materials for manufacture get into the cytoplasm, when they are absorbed across the cell membrane (the crispy brown bit at the edge of our fried egg). These raw materials are the amino-acids, sugars and vitamins etc., that we receive in our diet.

    To kick off the process, when a cell needs to make something, a signal is sent from the white of the egg (the cytoplasm) into the nucleus. That signal makes its way to the ball of wool or chromosome that contains the particular recipe, or code for the ingredients that will make up whatever is needed by the cell. When the signal reaches the chromosome containing the particular recipe or gene, the ball of wool is loosened slightly, and a relatively small length of closed zip (or DNA containing that recipe), is unzipped. One side of the opened zip is then copied into a piece of mRNA.

    That copy of one side of the unzipped zip is called messenger RNA. In most textbooks it (the mRNA) looks exactly as I have described it: a single side of a zip. This messenger RNA then exits through pores in the nucleus.  It enters the white of the egg, where this mRNA ‘recipe’ is then read or translated, and whatever it is the cell needs can now be manufactured within the cytoplasm or the white of the egg.

    The Ribosome

    When the strand of messenger RNA leaves the nucleus and enters the cytoplasm it is immediately found by a fascinating little cytoplasmic protein called a ‘ribosome’. The ribosome attaches to the mRNA. It then slides along this single strand of zip, and as it does so, ‘reads’ the code, and then makes a little strand, like a bead of pearls (a polypeptide). That strand of polypeptide then curls and folds itself into a little ball or blob; and this little blob of protein, is the very thing that the cell was looking for in the first place.

    It might be a structural protein, an enzyme, a building block, a replacement part, or whatever. When the ribosome slides along the piece of mRNA it makes this new little string that will ultimately fold upon itself to become the required product. This wonderful orchestral process is as ancient as life itself and is called ‘translation.’

    It is one of the rare occasions when jargon makes sense, for the little piece of mRNA, has indeed been ‘translated’ into a protein or ‘final product’ by the ribosome. The cell has now manufactured the thing that it needs, and after a few translations, the mRNA then degrades. No more ribosomes can attach to it, and no further product can be manufactured from it. If the cell wants another product it must send another message into the nucleus and call for another mRNA copy to be made in the nucleus and sent into the cytoplasm. It is a beautifully organised process, integral not simply to human life but to all life on the planet.

    How Does a Genetic-Vaccine Work?

    If you got all of that, you have grasped some of the fundamentals of cell biology and we are now able to ask: how does a genetic vaccine work?

    Most of us have seen an image or an artist’s impression of what a coronavirus looks like. A little ball, covered in spikes, like a medieval weapon swung from the end of a chain. Inside this little ball are the virus’s own genes. These genes are in the form of strands of RNA; the same type of RNA that is made in the nucleus of our cells, and sent into the cytoplasm for the manufacture of all ‘things’ that the cell needs.

    SARS-CoV-2

    The main difference between the RNA strands within a coronavirus, and those that naturally emerge from the nucleus of our own cells, is that coronavirus RNA does not code for ‘things’ that our cells might need. On the contrary, it codes for pieces that make up the coronavirus itself.

    When a coronavirus binds to the outside of one of the cells in our respiratory tract, it releases its RNA into those cells – into the white of the egg – and there, instead of making proteins that are needed by our cells, our ribosomes attach to their viral RNA and begin to manufacture (or translate) proteins that make up the physical structure of the virus. The host cell has now becomes a virus-making factory; the cytoplasm swells with viral particles; the cell bursts, and thousands of new viruses (virions) are released into the bloodstream, or the fluid that lies outside of the cell membrane.

    A genetic vaccine looks like, and functions, in almost exactly the same manner as the coronavirus itself. If a genetic vaccine could be visualised, it would look like a little sphere that encapsulates a piece of viral RNA or DNA (depending on which of the four vaccines we are considering). The role of the sphere is to protect the RNA or DNA inside the vaccine, and, most importantly, to bind it to human cells in a manner that will allow the piece of RNA or DNA to enter host cells at the site where the ‘vaccine’ is injected.

    For an RNA containing vaccine (Pfizer & Moderna) once the vaccine RNA gets inside our cells, our ribosomes attach and translate the RNA into a piece of the virus (one of the spike proteins). The host cell will then swell with spike proteins, and release them into the blood stream or body fluids outside the cell. There, the spike-protein will trigger the same immune response that Jenner and the traditional vaccines make use of.

    For DNA vaccines (Johnson & Johnson, AstraZeneca) the vaccine-DNA makes its way into the nucleus of our cells where it begins working (and is treated the same as our own DNA). It is copied into a piece of mRNA that will then travel into the cytoplasm and be translated by ribosomes into spike-proteins. Because genetic vaccines cannot infect cells, the process whereby a genetic-vaccine enters host cells is referred to as ‘transfection’.

    It is only after the transfected host cell releases spike-protein into the blood stream that our genetic-vaccine begins working in the ‘traditional’ way. In reality, it is the cellular process for the manufacture of things which has been hijacked, and the ‘traditional vaccine’ is being made inside one’s own cells. The ‘vaccine’ is released into our blood stream in the same way that a cell infected with a virus releases new virus into the blood stream or tissues.

    The final result might be the same, however, where a genetic-vaccine is different is in its mechanism it operates inside cells at a level of intimacy that Jenner could never have imagined. Because DNA vaccines enter the nucleus of our cells, and are treated as our own DNA, they come with a risk of damaging our own DNA, causing mutations, including, potentially, cancer. The potential is indeed an established fact. It is no less established than the fact that there is a link between smoking and cancer.

    Consider when a piece of synthetic DNA comes within intimate proximity of a relatively enormous coiled ball of DNA that is dynamically unwinding and unravelling in response to the daily activities of the cell. Is there a chance that this relatively small piece of synthetic DNA might become incorporated into or interfere with the normal function of our own DNA? Before Covid, the answer was an emphatic yes. However of late, the mere suggestion will undoubtedly be treated as something of a ‘conspiracy theory’.

    It is for this and other reasons that genetic-vaccines have not been previously licensed for use in humans prior to the current crisis. Thus, a 2013 paper[xiii] published in Germs, the respected Journal of Infectious Diseases lists the established disadvantages of DNA vaccines.

    Crossing the Rubicon

    At this point the reason critics refer to current Covid-19 vaccines as ‘gene therapy’ should not be too difficult to understand. It is important to bear in mind that as the cellular process of translation can be hijacked to produce a ‘vaccine’, it can also be hijacked to produce a myriad of other potential pharmaceutical therapies.

    Very limited forms of gene therapy are available in the treatment of terminal cancers. However, pharmaceutical companies have not been able to market this form of medicine, outside of the laboratory, on human populations.[xiv] A cynic might reasonably argue that companies are exploiting the current crisis in order to expedite safety trials and open the market for ‘gene-therapy’.

    There is nothing new here, this type of therapy, whereby patients are administered the gene for a missing or desired product, has been in development for several decades. The major difficulty for pharmaceutical companies has been how to get it out of the laboratory and past the paralysis of safety trials. It is certainly easy to see that if our cells are programmed to make and release spike-proteins, they can also be programmed to release other kinds of proteins, drugs and potential therapies directly into the human blood stream or tissues.[xv] Getting this type of therapy past regulators, and avoiding meaningful debate, has, (for better or worse), clearly been accomplished within the context of the current crisis.

    From a simple economic perspective, if human cells can be programmed to take on the role of manufacturing the ‘drug’, numerous difficulties in respect of production, costs, delivery, and even safety trials, are relatively easily overcome. The paradigm shift that resulted from Jenner’s development of vaccination could pale into insignificance compared to the potential game changer of genetic-vaccine.

    Ah go on. You’ll be grand!

    If, indeed, these vaccines are going to protect people from Covid-19, and they come with the added benefit of paving the way for novel therapies, why are people like me getting our proverbial knickers in a twist?

    Again the answer is not that complicated. The cellular process of ‘translation’ that is being ‘hijacked’ by the relevant pharmaceutical companies, does not belong to them, to our respiratory cells, or even human cells. As mentioned already, it is a process that belongs to ALL cells, in ALL species. In essence it ‘belongs’ to all living things in Nature.

    If anything happens to go wrong, the consequences are not limited to human beings, as the process being ‘hijacked’ is not exclusive to us. It ‘belongs’ to all life on Earth. The consequence of error, may extend further than a little nausea or swelling at the injection site.[xvi] Potential consequences extend to all cells that utilize the same process, and come in contact with the manufactured DNA or RNA.

    DNA or RNA? Red or White?

    Whilst the potential for either of the two available DNA vaccines to integrate into, or damage, human DNA is well established; there is an argument being made that this cannot possibly occur with the two available RNA vaccines.

    Generally speaking within our cells once RNA is copied or made in the nucleus it moves into the cytoplasm. It does not travel backwards. RNA does not move back inside the nucleus and incorporate into our DNA. However, the key words here are: ‘generally speaking.’

    Nature (generally speaking) blocks this possibility because the copied RNA that exits the nucleus, is different to DNA. It is an RNA copy of the DNA, the RNA cannot bind or interact with DNA. In the first instance RNA is a single stranded copy of one side of the zip. In the second instance the ‘teeth’ on the newly copied RNA are slightly different. They are tweaked with a sugar molecule called ribose, they are ‘ribosylated’ and therefore cannot readily recombine with DNA. (The ‘R’ in RNA simply means Ribosylated Nucleic Acid.)

    The RNA does indeed code for the same message that is contained within the DNA, but the teeth, or the letters of the RNA code, are slightly different. RNA does not travel backwards and interfere with DNA. Generally speaking they are incompatible, and cannot interfere with each other. Therefore, when the vaccine makers insist that the pieces of RNA that they have transfected into our cells do not interact with our DNA; well, they aren’t spoofing. It doesn’t normally happen that RNA interferes with DNA.

    So that’s what it says on the tin. However, there are two points that must be considered before we take this claim at face value. The first is a question of ‘precedence’ and the second is a question of scale.

    Does it happen in humans and in Nature that RNA can travel backwards into the nucleus and interfere with or incorporate into DNA? The simple answer to this question is a definite yes! RNA can and does travel backwards to incorporate itself into our DNA. This retrograde move, (where RNA sequences become incorporated into DNA) is called reverse-transcription. The reason for the use of ‘retro’ in the word retrovirus, is because retroviruses, and many other viruses, make use of reverse-transcription, converting RNA into DNA that will then integrate into our own DNA.

    HIV and HTLV (a human virus that causes t-cell leukaemia) are examples of viral infections, where RNA is converted backwards into DNA which then ‘interferes’ with our own DNA inside the nucleus of our cells. These viruses contain RNA, and they also carry an enzyme called ‘reverse transcriptase’. This enzyme converts RNA backwards into DNA. Retroviruses and other viruses (such as Hepatitis B) introduce the reverse-transcriptase enzyme into our cells when they infect them.[xvii] Furthermore, our own cells normally produce and use this enzyme (reverse transcriptase) inside the nucleus, where it has some ‘house-keeping’ roles in maintaining our own DNA.[xviii]

    Perhaps even more interesting is the fact that within the human genome some 8% of our DNA is composed of DNA that was originally viral RNA. Infections with RNA viruses whose genes have since become permanently incorporated into our own DNA. These sequences are called ‘Human Endogenous Retroviral Sequences’ or HERVS.[xix] Many of them persist within our genome because they may code for proteins or things that are likely to be of some benefit to us; genes brought into our genome from outside the cell, via the natural, dynamic interaction between viruses, retroviruses and human DNA.

    Many more of these endogenous retroviral (originally RNA) sequences are mysteriously redundant, and science is yet to learn of their function in sickness or in health. The fact remains that they are present; been present for countless millennia; may be integral to our evolution as a species; and are certainly with us ‘until death do us part.’ They should serve to remind us that there is a long established history of communication between viral and human genetics; an interaction that we should attempt to understand before it is blindly manipulated.

    Interconnectedness

    Too often viruses are portrayed as static structures, distinct from our own genetic material and distinct from one another. This is quite simply a rather primitive concept, the same kind of thinking that removes human beings and the consequence of our actions from Nature. It is part of the reason we remain largely incapable of seeing and appreciating the vast web of interconnectedness that dependently joins us to whales, rain forests, and even viruses.

    We depend upon viruses for our genetics, as we depend upon yeast for our beer. Often viruses depend upon each other to cause infection. In certain instances, if a particular virus is missing something, a part or component (without which it is defective or deficient), the missing part is supplied by another helper-virus. There are helper-viruses, and there is an entire family of viruses (dependoviruses) that are entirely dependent upon assistance from helper-viruses. For example, in Humans, Hepatitis D virus is activated, only in the presence of Hepatitis B virus. Essentially, in order to function, the D-virus ‘borrows’ some missing parts from the B virus.

    In short, viruses are not ‘monogamous recluses’: interacting with each other; helping each other; interacting with our genetic material within the cytoplasm and within the nucleus. It does not matters if that genetic material has come from the nucleus of our own cells, or been synthesized in the labs at Johnson and Johnson.[xx]

    A Question of Scale

    There is no such thing as a ‘perfect process’. Do something for the first time and you might do it right,  do it right enough times, and you will eventually do it wrong. 

    When vaccine RNA or DNA hijacks a natural cellular processes and transforms the cell to vaccine or spike-protein production; how many times does this ‘event’ occur in the tissue of the person who has thus been vaccinated? Thousands, or several thousands of times? How many times has it occurred when several billion people are vaccinated? I don’t know the answer to this question. However, when a process is repeated billions of times, mistakes are no longer ‘possible’, they are inevitable. Such mistakes or mutations are not only inevitable but are essential, lying at the heart of evolution itself.

    The End is Nigh?

    There is certainly a mountain of spin and delusion on either side of the ‘genetic-vaccine’ or ‘gene-therapy’ debate, and we must keep matters in perspective. Genetic modification is here to stay, for better or for worse. The argument in respect of unforeseen genetic consequence to ourselves and/or other species is an old one. It began with ‘Dolly’ the sheep, and has raged for some time around the desirability of genetically modified foods.

    Ironically, the introduction of synthetic genes into vegetables, created something of an international furore, yet the transfection of synthetic genes into millions of regular human beings has created far less controversy. Debate or discussion on the subject of genetic modification or therapy, its necessity, utility, or potential harm, is long overdue; although perhaps it might be a case of too little, too late.

    Today, many of the foods we eat have been genetically modified to some degree. Genetically modified food is, however, met with and processed by the acid and digestive enzymes in our guts. The synthetic genes in GM products do not (as far as we know) enter our cells, they do not attempt to manipulate our own cellular or genetic processes.

    There is clearly an urgent need to revisit this debate in light of these new vaccines. The battle may have been lost in respect of GM crops, but there is a reasonable argument to be advanced this time round as ‘human genetic processes’ are being tampered with, rather than sheep, beetroot or soya beans.

    The Right Hashtag?

    In recent years discourse and protest have become strangely predictable, organised around or stimulated by whatever happens to be trending on social media. It seems the right hashtag hasn’t been developed for ‘debate’ in respect of current pandemic policy, even as that policy extends into the function of our own cells.

    How many people in Ireland, or around the world, know how a Covid vaccine work? How many clinicians are aware for that matter? When debate does erupt in relatively small pockets around the country it is hijacked by extremists or dismissed as being organised and attended by extremists. Social media appears to be moderating our behaviour to a greater degree than even genetics.

    The health of our society depends far more on constructing a more honest and happier version of ourselves. We need to re-evaluate materialism, define happiness, reduce consumption, eat less (or no) meat, take plastics out of our food chain and ecosystems, restore and preserve habitats, protect and understand a biodiversity upon which we are entirely dependent. All of this, and more, is not contingent on genetic modification, no more than it is dependent on us getting to Mars.

    Therefore, for the reasons I have outlined, I would not inject a healthy animal with an experimental genetic-vaccine, never mind a healthy human being.

    [i] Jonathan Corum and Carl Zimmer, ‘How the Oxford-AstraZeneca Vaccine Works,’ New York Times, March 22nd, 2020,  https://www.nytimes.com/interactive/2020/health/oxford-astrazeneca-covid-19-vaccine.html

    [ii] Smriti Mallapaty, ‘The coronavirus is most deadly if you are older and male — new data reveal the risks’ August 28th, 2020, https://www.nature.com/articles/d41586-020-02483-2

    [iii] Adam W. Gaffney, ‘We need to start thinking more critically — and speaking more cautiously — about long Covid’ Statnews, March 22nd, 2021, https://www.statnews.com/2021/03/22/we-need-to-start-thinking-more-critically-speaking-cautiously-long-covid/

    [iv] Conor Pope, Vivienne Clarke, ‘Vaccination rollout in nursing homes almost complete, HSE says,’ February 12th, 2020, Irish Times, https://www.irishtimes.com/news/health/vaccination-rollout-in-nursing-homes-almost-complete-hse-says-1.4483250

    [v] CSO. https://www.cso.ie/en/releasesandpublications/ep/p-covid19/covid-                                                19informationhub/health/covid-19deathsandcasesstatistics/

    [vi] Moderna Announces First Participants Dosed in Phase 2/3 Study of COVID-19 Vaccine Candidate in Pediatric Population https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-first-participants-dosed-phase-23-study-0

    [vii] CSO. https://www.cso.ie/en/releasesandpublications/ep/p-covid19/covid-                                                19informationhub/health/covid-19deathsandcasesstatistics/

    [viii] https://www.google.com/search?client=firefox-b-d&q=covid+deaths+ireland

    [ix] ‘Immune evasion means we need a new COVID-19 social contract’, The Lancet, February 18th, 2021, https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(21)00036-0/fulltext

    [x] Jeremy Divine, ‘The Dubious Origins of Long Covid’, Wall Street Journal, March 22nd, 2021,  https://www.wsj.com/articles/the-dubious-origins-of-long-covid-11616452583

    [xi] Angela Betsaida B. Laguipo, ‘86 percent of the UK’s COVID-19 patients have no symptoms,’ News Medical Life Sciences, October 9th, 2020, https://www.news-medical.net/news/20201009/86-percent-of-the-UKs-COVID-19-patients-have-no-symptoms.aspx

    [xii] The History of Vaccines, Chinese Smallpox Inoculation, https://www.historyofvaccines.org/content/early-chinese-inoculation

    [xiii] Germs. 2013 Mar; 3(1): 26–35. Published online 2013 Mar 1. doi: 10.11599/germs.2013.1034/

    [xiv] Kristina Fiore, ‘Want to Know More About mRNA Before Your COVID Jab?’ Medpage Today, December 3rd, 2020, https://www.medpagetoday.com/infectiousdisease/covid19/89998

    [xv] Nature Reviews Drug Discovery volume 17, pages261–279(2018)

    [xvi] Nicola Davis, ‘Covid vaccine side-effects: what are they, who gets them and why?’ The Guardian, March 18th, 2021, https://www.theguardian.com/world/2021/mar/18/covid-vaccine-side-effects-what-are-they-who-gets-them-and-why

    [xvii] Medical Microbiology. 4th edition (Chapter 62).Galveston (TX): University of Texas Medical Branch at Galveston; 1996.

    [xviii] Proc Natl Acad Sci U S A. 1986 Apr; 83(8): 2531–2535.
    doi: 10.1073/pnas.83.8.2531, https://www.nature.com/articles/1205081

    [xix] PMCID: PMC7139688 PMID: 32155827 Human Endogenous Retroviruses (HERVs): Shaping the Innate Immune Response in Cancers.

    [xx] Knipe, David M.; Howley, Peter M. (2007). Fields Virology (5th ed.). Lippincott Williams & Wilkins. pp. 126–7.